Tomasovic, A., Kurrle, N., Sürün, D., Heidler, J., Husnjak, K., Poser, I., Schnütgen, F., Scheibe, S., Seimetz, M., Jaksch, P., Hyman, A., Weissmann, N., and von Melchner, H.
Sestrin 2 Protein Regulates Platelet-derived Growth Factor Receptor beta (Pdgfrbeta) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions.
J. Biol. Chem., 290, 9738-9752 (2015)
Rabenhorst, U., Thalheimer, F. B., Gerlach, K., Kijonka, M., Bohm, S., Krause, D. S., Vauti, F., Arnold, H. H., Schroeder, T., Schnütgen, F., von Melchner, H., Rieger, M. A., and Zörnig, M.
Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.
Cell Rep., 11, 1847-1855 (2015)
Bultmann-Mellin, I., Conradi, A., Maul, A. C., Dinger, K., Wempe, F., Wohl, A. P., Imhof, T., Wunderlich, F. T., Bunck, A. C., Nakamura, T., Koli, K., Bloch, W., Ghanem, A., Heinz, A., von Melchner, H., Sengle, G., and Sterner-Kock, A.
Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.
Dis. Model. Mech., 8, 403-415 (2015)
Noda, K., Dabovic, B., Takagi, K., Inoue, T., Horiguchi, M., Hirai, M., Fujikawa, Y., Akama, T.O., Kusumoto, K., Zilberberg, L., Sakai, L.Y., Koli, K., Naitoh, M., von Melchner, H., Suzuki, S., Rifkin, D.B., and Nakamura, T.
Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.
Proc Natl Acad Sci U S A, 110, 2852-2857 (2013)
Heidler, J., Fysikopoulos, A., Wempe, F., Seimetz, M., Bangsow, T., Tomasovic, A., Veit, F., Scheibe, S., Pichl, A., Weisel, F., Lloyd, K.C., Jaksch, P., Klepetko, W., Weissmann, N., and von Melchner, H.
Sestrin-2, a repressor of PDGFRbeta signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Dis Model Mech, , (2013)
Hahn, M., Dambacher, S., Dulev, S., Kuznetsova, A.Y., Eck, S., Worz, S., Sadic, D., Schulte, M., Mallm, J.P., Maiser, A., Debs, P., von Melchner, H., Leonhardt, H., Schermelleh, L., Rohr, K., Rippe, K., Storchova, Z., and Schotta, G.
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
Genes Dev., 27, 859-872 (2013)
Bradley, A., Anastassiadis, K., Ayadi, A., Battey, J.F., Bell, C., Birling, M.C., Bottomley, J., Brown, S.D., Burger, A., Bult, C.J., Bushell, W., Collins, F.S., Desaintes, C., Doe, B., Economides, A., Eppig, J.T., Finnell, R.H., Fletcher, C., Fray, M., Frendewey, D., Friedel, R.H., Grosveld, F.G., Hansen, J., Herault, Y., Hicks, G., Hörlein, A., Houghton, R., Hrabe de Angelis, M., Huylebroeck, D., Iyer, V., de Jong, P.J., Kadin, J.A., Kaloff, C., Kennedy, K., Koutsourakis, M., Lloyd, K.C., Marschall, S., Mason, J., McKerlie, C., McLeod, M.P., von Melchner, H., Moore, M., Mujica, A.O., Nagy, A., Nefedov, M., Nutter, L.M., Pavlovic, G., Peterson, J.L., Pollock, J., Ramirez-Solis, R., Rancourt, D.E., Raspa, M., Remacle, J.E., Ringwald, M., Rosen, B., Rosenthal, N., Rossant, J., Ruiz-Noppinger, P., Ryder, E., Schick, J.Z., Schnütgen, F., Schofield, P., Seisenberger, C., Selloum, M., Simpson, E.M., Skarnes, W.C., Smedley, D., Stanford, W.L., Stewart, A.F., Stone, K., Swan, K., Tadepally, H., Teboul, L., Tocchini-Valentini, G.P., Valenzuela, D., West, A.P., Yamamura, K., Yoshinaga, Y., and Wurst, W.
The mammalian gene function resource: the International Knockout Mouse Consortium.
Mamm. Genome, 23, 580-586 (2012)
Schnütgen, F., Ehrmann, F., Ruiz-Noppinger, P., and von Melchner, H.
High throughput gene trapping and postinsertional modifications of gene trap alleles.
Methods, 53, 347-355 (2011)
Schnütgen, F., Ehrmann, F., Poser, I., Hubner, N.C., Hansen, J., Floss, T., deVries, I., Wurst, W., Hyman, A., Mann, M., and von Melchner, H.
Resources for proteomics in mouse embryonic stem cells.
Nature Meth. 8, 103-104 (2011)
Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, S. P., Vanhaelen, Q., Shukalyuk, A. I., Schmauss, G., Schramek, D., Schnütgen, F., von Melchner, H., Ecker, J. R., Stanford, W. L., Zuber, J., Stark, A., and Penninger, J. M.
Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells.
Cell Stem Cell 9, 563-574 (2011)
Wempe, F., De-Zolt, S., Koli, K., Bangsow, T., Parajuli, N., Dumitrascu, R., Sterner-Kock, A., Weissmann, N., Keski-Oja, J., and von Melchner, H.
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Dis. Model Mech. 3, 246-253 (2010)
Schnütgen, F., Hansen, J., De-Zolt, S., Horn, C., Lutz, M., Floss, T., Wurst, W., Noppinger, P.R., and von Melchner, H.
Enhanced gene trapping in mouse embryonic stem cells.
Nucl. Acids Res. 36, e133, (2008)
Horn, C., Hansen, J., Schnütgen, F., Seisenberger, C., Floss, T., Irgang, M., De-Zolt, S., Wurst, W., von Melchner, H., and Ruiz, P.
Splinkerette PCR for more efficient characterization of gene trap events.
Nat. Genet. 8, 933-934, (2007)
Schnütgen, F., De-Zolt, S., Van Sloun, P., Hollatz, M., Floss, T., Hansen, J., Altschmied, J., Seisenberger, C., Ghyselinck, N. B., Ruiz, P., Chambon, P., Wurst, W., and von Melchner, H.
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
Proc. Acad. Natl. Sci. USA 102, 7221-7226, (2005)
Skarnes, W. C., von Melchner, H., Wurst, W., Hicks, G., Nord, A. S., Cox, T., Young, S. G., Ruiz, P., Soriano, P., Tessier-Lavigne, M., Conklin, B. R., Stanford, W. L., and Rossant, J.
A public gene trap resource for mouse functional genomics.
Nat. Genet. 36, 543-544, (2004)
Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies, K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., de Angelis, M. H., Jackson, I., Kioussis, D., Kollias, G., Lathrop, M., Lendahl, U., Malumbres, M., von Melchner, H., Muller, W., Partanen, J., Ricciardi-Castagnoli, P., Rigby, P., Rosen, B., Rosenthal, N., Skarnes, B., Stewart, A. F., Thornton, J., Tocchini-Valentini, G., Wagner, E., Wahli, W., and Wurst, W.
The European dimension for the mouse genome mutagenesis program.
Nat. Genet. 36, 925-927, (2004)
Austin, C. P., Battey, J. F., Bradley, A., Bucan, M., Capecchi, M., Collins, F. S., Dove, W. F., Duyk, G., Dymecki, S., Eppig, J. T., Grieder, F. B., Heintz, N., Hicks, G., Insel, T. R., Joyner, A., Koller, B. H., Lloyd, K. C., Magnuson, T., Moore, M. W., Nagy, A., Pollock, J. D., Roses, A. D., Sands, A. T., Seed, B., Skarnes, W. C., Snoddy, J., Soriano, P., Stewart, D. J., Stewart, F., Stillman, B., Varmus, H., Varticovski, L., Verma, I. M., Vogt, T. F., von Melchner, H., Witkowski, J., Woychik, R. P., Wurst, W., Yancopoulos, G. D., Young, S. G., and Zambrowicz, B.
The knockout mouse project.
Nat. Genet. 36, 921-924, (2004)
Hansen, J., Floss, T., Van Sloun, P., Füchtbauer, E.M., Vauti, F., Arnold, H.H., Schnütgen, F., Wurst, W., von Melchner, H. and Ruiz, P.
A large scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Proc. Acad. Natl. Sci. USA 100, 9918-9922, (2003)
